The (DRI) FOXO4 is a cell penetrating peptide shown to selectively induce apoptosis of senescent cells reversing effects of aging in mice.


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The D-retro inverso (DRI)-isoform of FOXO4 is a cell penetrating peptide shown to selectively induce apoptosis of senescent cells thereby reversing effects of aging in mice. Importantly, the TFA salt has been removed.

D-Retro Inverso (DRI)-isoform of FOXO4 is a synthetic peptide that is derived from the FOXO4 protein, a member of the forkhead box O (FOXO) family of transcription factors. The compound is being studied for its potential anti-aging effects. FOXO4 is known to play a role in various cellular processes such as cell growth, differentiation and apoptosis. It is believed that this DRI-isoform may be able to mimic the activity of the natural FOXO4 protein and promote the expression of certain genes associated with longevity and cellular health.

However, it is important to note that there is a lack of scientific evidence to support the safety or efficacy of D-Retro Inverso (DRI)-isoform of FOXO4 and it is not FDA approved. FOXO4-DRI is only being studied in laboratory settings and more research is needed to confirm its potential benefits and to determine the appropriate dosage.

Sequence: H-D-Leu-D-Thr-D-Leu-D-Arg-D-Lys-D-Glu-D-Pro-D-Ala-D-Ser-D-Glu-D-Ile-D-Ala-D-Gln-D-Ser-D-Ile-D-Leu-D-Glu-D-Ala-D-Tyr-D-Ser-D-Gln-D-Asn-D-Gly-D-Trp-D-Ala-D-Asn-D-Arg-D-Arg-D-Ser-D-Gly-D-Gly-D-Lys-D-Arg-D-Pro-D-Pro-D-Pro-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-D-Lys-D-Lys-D-Arg-D-Gly-OH

Purity: >98%

BuckyLabs is proud to be the first company who offered FOXO4-DRI with in-stock availability.

Research: Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Storage: FOXO4 D-Retro-Inverso(DRI) should be stored in a freezer at or below -9C. After reconstitution, FOXO4 D-Retro-Inverso(DRI) peptide should be kept refrigerated. See the MSDS for more details about safety and handling. They are shipped it with two frozen gel packs, but depending on weather etc, these only last about 2 days. It is highly recommended to go with our next day courier shipping available. We do not advise on dosages or use of this product. This substance is not sold for human use. Peptides and proteins are non-returnable.

Warning: Peptide products are not intended for human consumption. They are intended for laboratory research purposes only. These products are not FDA approved and their safety and efficacy have not been established. Handling and use of peptides must be done by trained professionals in a laboratory setting. Improper use or handling of peptides can be dangerous and may result in serious injury or death. Keep out of reach of children and pets. Consult with a qualified healthcare professional before handling or using these products.

Additional information

Weight 0.006 kg
Dimensions 1.905 × 1.905 × 3.81 cm

5mg, 10mg, 20mg, 50mg


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